Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and biological evaluation of 6-fluoro benzothiazole substituted pyrazolo azetidinones
Author(s): D. Ravi Sankar Reddy and Risy Namratha. JIn the present work, 2-amino benzothiazoles were synthesized from 3-chloro-4-fluoro aniline and further condensed with 3-methyl-1-phenyl-5-Pyrazolone to yield the corresponding Schiff’s base. The Schiff’s base was cyclised with chloroacetyl choride in triethylamine to yield 2-azetidinones. The formed 2-azetidinones were further condensed with different primary and secondary amines. The synthesized compounds were confirmed by spectral analysis such as IR, 1H-NMR, Mass and were screened for Anti-inflammatory, Anti-diabetic, Anti-oxidant and Anti-microbial activity.
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Citations : 15261
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