Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and biological evaluation of 3-methyl- 2-pyrazolin-5-one derivatives containing thiazole and indole moieties
Author(s): Mohamed S. Mostafa and Nasser M. Abd El-SalamIn the present work six 3-methyl-1-[(5-substituted-1H-indol-2-yl) carbonyl]-4-{[4- (substituted thiazol-2- yl)iminoethyl) phenyl ]hydrazono}-2-pyrazolin-5-one derivatives were synthesized by conventional and microwave methods. The synthesized compounds were tested for their antimicrobial activity against six strains of bacteria and three fungal strains. Compound 5a showed a broad spectrum of activity against bacteria and compound 5d exhibited excellent antifungal activity, while most of the other compounds showed varying antimicrobial activity.
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