Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and biological activity of 4-bromo-2-hydroxy-N-(5- methylene-4-oxo-2-aryl-thiazolidin-3-yl) benzamide
Author(s): Sonal Maheta4-bromo-2-hydroxy benzoic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-bromo-2-hydroxy benzoic acid arylidene hydrazides (2a-h) in good yields. Cyclocondensation of compounds (2a-h) with thioglycolic acid yields 4-bromo-2-hydroxy- N (4-oxo-2-aryl- thiazolidin -3-yl) benzamides (3a-h). These (3a-h) compounds are for the reacted with benzaldehyde in the presence of sodium ethanolate affords, giving 4-bromo-2-hydroxy- N (5-methylene-4-oxo-2-aryl- thiazolidin -3- yl)benzamides (4a-h). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
