Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and antitumor activity of novel pyrazolo[3,4-d]pyrimidines and related heterocycles
Author(s): Manal M. Kandeel , Sameha M. Ali, Eman K. A. Abed ElALL, Mohamed A. Abdelgawad , and Phoebe F. LamieThe reaction between 5-amino-4-imino-3-methyl-1-phenyl-1,4-dihydro-pyrazolo[3,4-d]pyrimidine (2a) or (3- methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)- hydrazine (3) and several available reactants afforded new heterocycles with pyrazolo[3,4-d]pyrimidine nucleus. Some of the newly synthesized compounds were screened against MCF-7 cell line, compounds 4b, 5a, 10c and 12c showed the highest activity among the tested compounds with IC50 between 0.013 and 0.018 μM.
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