Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and Antitubercular Screening of 2-Chloro-N-(3-Cyano-4,5,6,7-Tetrahydro-1-Benzothiophen-2-Yl)Acetamide Clubbed Substituted 5-Phenyl-1,3,4-Oxadiazole-2-Thiol
Author(s): Prakash K Johi, Bharat B Patel, Maharshi B Shukla, Jigar S Patel, Jyotindra B MahyavanshiReactions of 2-chloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)acetamide with substituted 5-phenyl-1,3,4-oxadiazole-2 thiol gave N- (3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-aryl-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide were synthesized and assessed for their efficacy as antitubercular agents against tuberculosis H37Rv. The structural assignments of the new products were done on the basis of Infrared radiation (IR), Proton nuclear magnetic resonance (1H-NMR) and elemental analysis.
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