Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and antitubercular activity of some novel N-methyl triazolone derivatives
Author(s): Pramod B. Patil*, Suhas S. Awati, Sachin R. Kumbhoje, Rajanikant B. Ghotane and Shitalkumar S. PatilThe N-methyl Triazolone is prepared by methylation of triazole-5-one which was further converted in to the respective acids by reacting with p-amino benzoic acid (Mannich base condensation). The same was converted to ester and then to hydrazides. From this the various Schiff bases with aldehydes were prepared. The structures of the synthesized Compounds were evaluated by IR, 1H NMR spectra Mass Spectroscopy and elemental method of analysis. All the synthesized compounds were screened for their anti-tubercular activities. Anti-tubercular activity was carried out by using middle brook 7H9 broth base (M198) medium against Mycobacterium tuberculosis. Compounds P4 and P5 showed very significant activity while P1, P2 & P3 showed moderate antitubercular activity. Streptomycin and Pyrizinamide were used as standard drugs.
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