Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and antimicrobial studies of some novel pyrazolines
Author(s): S.Shah N.N, Biradar A.S., Seema I Habib, Dhole J.A., M.A.Baseer and Kulkarni P.APyrazolines are well known biologically important nitrogen containing heterocycles. Nitrogen containing heterocyclic compounds [1] like pyrazolines have received considerable attention in recent years. Pyrazolines exhibit a plethora of bioactivities viz, COX-2 inhibitior[2], antiandrogenic[3], antibacterial[4], antifungal[5], antitumor[6], antidepressant[7], insecticidal[8], antidiabetic[9], photochemical[10],herbicidal[11] molluscicidal[12], antinociceptive[13] and antiamoebic activity[14]. Pyrazolines are also used in the treatment of Parkinson’s, Alzehimer’s disease and Cerebral edema[15]. Besides Being Biologicallly active they are also used as useful synthons in organic synthesis[16-18]. Hence synthesis of Pyrazolines are largely on account of their biological activity. Herein we report the synthesis of some novel pyrazolines by using the chalcones and hydrazine hydrate.
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