Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and antimicrobial activity studies of microwave irradiated in (4-chlorophenyl) (6-methylpyridin-3-yl) derivatives
Author(s): S. M. Reddy, Bijivemula N. Reddy and Madhvesh PathakIn view of generating new compounds for future drug development, we have synthesized some (4-chlorophenyl)(5- methylpyrazin-2-yl)derivatives of 5-methylpyrazine-2-carboxylic acid (1a) in presence of triethylamine followed, NH(OCH3)CH3.HCl and 4-chlorophenyl)magnesium bromide to obtaine (4-chlorophenyl) (5-methylpyrazin-2-yl) methanone (4a) as one of the major product which was then used as an intermediate to synthesize a new series of compounds (5a-j). All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and were evaluated for their antimicrobial activities in two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtillis) and two Gram-negative bacteria (Echerichia coli and Pseudomonas aeuroginosa) and two fungi (Aspergillus niger and Aspergillus fumigatus) strains using Cup plate method
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Citations : 15261
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