GET THE APP

Synthesis and antimicrobial activity of some novel 4-oxo-1,3-thiazolidines tethered to phthalimido moiety | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and antimicrobial activity of some novel 4-oxo-1,3-thiazolidines tethered to phthalimido moiety

Author(s): A. Cendil Kumar, R. Vidhya, Rishikesh Vilas Antre and V. Sivajothi

In present research work, phthalimide is esterified with chloro ethylacetate followed by amination using hydrazine hydrate. Thus formed phthalimido acetohydrazide (2) was condensed with various substituted aldehydes to yield Arylidene phthalimido acetohydazides (Schiff bases) (3a-3j) which on cycloaddition with thioglycollic acid yield arylidene 4-oxo-1,3-thiazolidine phthalimido acetohydrazides (4a-4j). Structures of all the synthesized compounds were identified and characterized by melting point determination, TLC, FT-IR, 1H NMR and Mass spectral analysis. Compounds (3a-3j) & (4a-4j) were screened for their antimicrobial activity viz., antibacterial and antifungal activity using Ciprofloxacin and Ampicillin as standard drugs for antibacterial activity; Fluconazole and Amphotericin B as standard for antifungal activity.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry