Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and antimicrobial activity of novel 1,3,4-thiadiazine derivatives Vijay V. Dabholkar*, Prem Naik, Abhishek Karekar and Navnath Shinde
Author(s): Vijay V. Dabholkar, Prem Naik, Abhishek Karekar and Navnath ShindeCompound (1) was treated with phenacyl bromide to yield compound (3), which was brominated to yield compound (4) and Further condensed with piperazine ester to obtained compound (6). Compound (6) was treated with hydrazine hydrate to obtained compound (7), which on further treatment with aromatic aldehydes which yielded corresponding Schiff base compound (8). Compound (8) in acidic medium undergoes cyclization to yield respective novels thiadiazine derivatives(9). The structures of the newly synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopic analysis.
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