Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and antimicrobial activity evaluation of new dialkyl heteroarylphosphonates
Author(s): K.Venkata Ramana, K. C. Venkata Subbaiah, V. Lokanatha and C. Naga RajuSynthesis of new dialkyl heteroaryl phosphonates (4a-f and 5a-f) is accomplished with high yields via Michaelis-Arbuzov rearrangement by the reaction of various heteroaryl halides with triethyl /triisopropyl phosphite at 50-55 °C in dry tetrahydrofuran (THF) in the presence of BF3.Et2O as a catalyst. The structures of the title compounds were established by elemental analysis and spectral data (IR, 1H, 13C and 31P NMR and LC- mass) and their antimicrobial activity was evaluated. The title compounds exhibited moderate antimicrobial activity.
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