Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and antimicrobial activities of 2-azetidinone and its derivatives
Author(s): M. M. Murhekar and R. E. KhadsanIn present research work , 2-aminobenzothiazole is condensed with different aromatic aldehydes in ethanol to yield corresponding Schiff bases. The Schiff bases were cyclised with chloroacetyl choride in triethyl amine to yield the corresponding 2-Azetidinones. The structures of synthesized compounds were confirmed by elemental and spectral analysis such as IR, NMR, Mass, GC-MS. The compounds were evaluated for their antimicrobial properties against microorganisms such as S. aureus , B. substilis., B megatherium, E. coli, S. typhie, P.aeruginosa.
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Citations : 15261
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