Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and Anti-inflammatory activity of novel 2-chloro-4-(aryl amino)-6, 7-dimethoxy quinazoline derivatives
Author(s): Poonam Rani*, Manoj Kumar, Sonali and Bhupender NehraTo explore the anti-inflammatory potential of novel quinazoline consisted heterocyclic derivatives, a new series of 2-chloro-4-(aryl amino)-6, 7- dimethoxy quinazoline derivatives (1-4) were design and synthesized using multistep synthetic methodology. Structural elucidation of all synthesized molecules was performed by using FT-IR and 1H NMR spectral reports. All molecules were accessed for their anti-inflammatory potential against while taking diclofenac sodium as reference anti-inflammatory agent. Many compounds exhibited good anti-inflammatory activity in which compound 4 possessed the highest activity amongst the synthesized series with IC50 value of 1.772 μg/ml.
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Citations : 15261
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