Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and Anti-Inflammatory Activity of New Substituted 4,5- Dihydro-3-(Naphthalene-6-Yl)-5-Phenyl Pyrazole Carbothio Aminde Derivatives
Author(s): Poonam K, Priya M, Anshuman S, Bhumika Y, Sujeet KGIn the present study we have made an attempt to synthesize substituted 4,5-dihydro-3-(naphthalene-6-yl)-5-phenyl pyrazole carbothioamide derivatives (2a-i) and evaluate them for anti-inflammatory activity using carrageenan induced rat paw edema model. In the first step, 2-acetylnaphthalene (1) was allowed to react with substituted benzaldehyde (2) in equimolar amount with sodium hydroxide to form various substituted derivatives (1a-i). Further substituted chalcone derivatives on treatment with thiosemicarbazide in the presence of ethanol corresponding substituted 4,5-dihydro-3-(naphthalene-6-yl)-5-phenyl pyrazole carbothioamide (2a-i). The structure of the final analogues has been confirmed on the basis of elemental analysis, Fourier Transform Infrared (FTIR), Proton Nuclear Magnetic Resonance (1H-NMR). All the values of elemental analysis, FTIR, 1H-NMR were found to be prominent. Among all synthesized compounds for anti-inflammatory activity compounds 2d and 2h were found to be most potent in comparison with standard diclofenac.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
