Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and anticancer evaluation of 5-benzyl-1,3,4-thiadiazol-2-amine derivatives on Ehrlich ascites carcinoma bearing mice
Author(s): Subbiah Ramasamy, Tanmoy Guria, Tanushree Singha, Puspita Roy, Benu P. Sahu, Jayatri Naskar, Avijit Das and Tapan K Maity5-benzyl-1,3,4-thiadiazol-2-amine derivatives (2-12) were synthesized by reaction of 5-benzyl-1,3,4-thiadiazol-2- amine with different substituted phenyl isocyanates or phenyl isothiocyanates. Structures of all compounds were established on the basis of FT-IR, 1HNMR, and LC-MS spectral data. The effects of all compounds on in-vivo tumor growth inhibition were evaluated by studying the parameters such as tumor volume, tumor cell count (viable and non-viable), haematological values, and mean survival time of carcinoma cells bearing mice. Among the tested compounds, compound 2 (54.63%), 3 (60.8%), and 11 (51.54%) showed significant tumor growth inhibition and compared favourably with the standard anticancer drug 5-fluorouracil
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Citations : 15261
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