Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and Anticancer Activity of Certain Fused Pyridazine Derivatives
Author(s): Salwa Elmeligie, Eman M. Ahmed, Suzan M. Abuel-Maaty and Demiana S. MikhailNovel series of pyridazine containing compounds were synthesized through the reaction of N-carbamimidoyl-4-[(6 chloropyridazin-3-yl) amino]benzenesulphonamide 1 with either 2-aminophenol, acetophenone phenylhydrazone derivatives, anthranilic acid derivatives, thiosemicarbazide or substituted benzoyl hydrazide to afford the corresponding derivatives 2, 3a-c, 4a-d, 5 and 6a-c respectively. The structure of the newly synthesized compounds was characterized by spectroscopic means and elemental analysis. All the synthesized compounds were screened for their anticancer activity in vitro on colon cancer cell line (HCT-116) and breast cancer cell line (MCF-7). Compound 4a showed potent anticancer activity against colon cancer cell line (HCT-116) with IC50 11.90 μM in comparison to imatinib (Gleevec ®).
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
