Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and anticancer activity of 4-hydroxy naphtho coumarin derivatives and naphtho coumestans
Author(s): Shubhangi S. Soman*, Jigar N. Soni, Gajanan S. Inamdar and Gavin P. RobertsonWe have synthesized various coumestan derivatives from 4-hydroxy-2H-benzo[h]chromen-2-one 2. Oxidative cyclization of 4-hydroxy-2H-benzo[h]chromen-2-one with catechol and pyrogallol in presence of sodium acetate and potassium iodate gave 8, 9-dihydroxy-6H-benzo[h]benzofuro[3,2-c]chromen-6-one 3 and 8, 9, 10-trihydroxy- 6H-benzo[h]benzofuro[3,2-c]chromen-6-one 4 respectively. These coumestan derivatives and 4-hydroxy-2Hbenzo[ h]chromen-2-one were condensed with dimethyl sulphate and different mono and/or di alkyl halides in presence of base like anhydrous K2CO3 and dry acetone gave corresponding condensed or cyclized coumestan 6a-d, 7a-d and 4-hydroxy-2H-benzo[h]chromen-2-one 5a-b derivatives.
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Citations : 25868
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