Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and activity of conformationally rigidized N1-substituted-3-amino alkoxy indoles using intramolecular Heck reaction
Author(s): Ramakrishna V. S. Nirogi1, Anand V. Daulatabad1, 2, Anil K. Shinde1*, K. R. Sastry1 and P. K. DubeyA novel series of conformationally rigidized N1-substituted-3-aminoalkoxy indoles (tetracyclic derivatives) were designed and synthesized using intramolecular Heck cyclization in presence of tetrakis triphenyl phosphine palladium (0) catalyst. The compounds were characterized with spectral data and were tested for human 5-HT6 receptor binding affinities. All the compounds showed moderate binding affinities towards human 5-HT6 receptor.
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Citations : 15261
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