Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, acute toxicity and modeling docking studies of azo compound derived from sulphonamide and pyrimidine derivative
Author(s): Wasfi A. Al-Masoudi, Mohammed A. Al-Diwan and Ishra q J. HassanA new azo pyrimidine derivative compound was synthe sized by reaction of 6-chloropyrimidine-2,4-diamine with 4- aminobenzenesulfonamide via diazotization to give n ovel 4-[(Z)-(2,4-diamino-6-chloropyrimidin-5- yl)diazenyl]benzene- sulfonamide in good yield. C haracterization of synthesized compound was carried by elemental analysis, I R, 1 H and 13 C NMR spectroscopy. The toxicity of new compound was assayed via the determination of their LD 50 value by using Dixon , s up and down method. Studied compound was found to have an LD 50 of 718.6 mg/kg of body weight. Molecular modeling studies were performed, showing the hydrogen bindin gs and hydrophobic interactions.
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