Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Syntheses and antibacterial activity of some 1-phenyl-3-(4-(4-butanoloxy) phenyl)-5-aryl-1H-pyrazoles
Author(s): Anju Goyal and Sandeep JainA series of 1-phenyl-3-(4-(4-butanoloxy) phenyl)-5-aryl-1H-pyrazoles were synthesized from chalcones i.e., 3-aryl-1-(4-hydroxyphenyl) prop-2-en-1-ones and studied for their in vitro antibacterial activity. Chalcones 1 on reaction with phenyl hydrazine yielded the corresponding 1-phenyl-3-(4-hydroxyphenyl)-5-aryl-1H-pyrazoles 2 which on further reaction with 4- chlorobutanol furnished the title compounds 3. These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and their minimum inhibitory concentration (MIC) were determined.
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