Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Substituted 1,4-naphthoquinones as a new class of antimycobacterial agents
Author(s): Alka Mital, Mukesh Sonawane, Sachin Bindal, Sunil Mahlavat and Villendra NegiNaphthalene-1,4-dione compounds possess a wide spectrum of biological activities. In the present study, a series of 1,4-naphthoquinone compounds were synthesized by reacting substituted naphthoquinones with alkyl or aryl amines in presence of a base. The synthesized compounds were screened against Mycobacterium tuberculosis (M. tb) H37Rv, where most of the compounds exhibited significant in vitro antitubercular activities and may serve as a lead for further optimization. Compounds 1, 18, 20 & 25 have IC90 values ranging from 3.14-3.43 μg/mL. The objective of our study is to generate new leads that operate through a different mode of action and to optimize their structure to display potent efficacy.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
