Studies of novel heterocyclic compounds

H. J. Shah; J. A. Chaudhari

Abstract

Studies of novel heterocyclic compounds

Author(s): H. J. Shah and J. A. Chaudhari

Novel heterocyclic compound namely, 4-((1-((4-((dialkylamino)methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2- yl)methyl)-1H-benzo[d]imidazol-2-yl)methylamino)-N-(pyrimidin-2-yl)benzenesulfonamide(4a-e) have been prepared by mannich reaction, a N-(pyrimidin-2-yl)-4-((1-((5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)-1Hbenzo[ d]imidazol-2-yl)methylamino) benzenesulfonamide(3) react with formaldehyde and different secondary amines. The compound (3) prepared from 4-((1-(2-hydrazinyl-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)methylamino)- N-(pyrimidin-2-yl)benzenesulfonamide(2) with CS2/KOH. 4-((1H-benzo[d]imidazol-2-yl)methylamino)-N- (pyrimidin-2-yl)benzene sulfonamide(1) react with chloro acetic acid and hydrazine hydrate gives compound (2).All the structures of novel synthesized compounds were established on basis of analytical and spectral data. The newly synthesized compounds were studied for their antibacterial and antifungal activities.

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