Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
STABILITY INDICATING RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF SALICYLIC ACID AND KETOCONAZOLE IN SHAMPOO FORMULATION
Author(s): Dilip Kowndinya B*, Basava Rao VV and Sailu CHA reverse phase HPLC method was developed and validated for the simultaneous estimation of Salicylic acid and Ketoconazole in shampoo formulation. Separation of the drugs was done using Kromasil C18 (250×4.6mm, 5μ) column at 322 nm using a mobile phase comprising of Acetonitrile: Buffer (0.01 N Potassium dihydrogen orthophosphate adjusted to a PH of 5.4 using dilute Orthophosphoric acid) in the ratio of 50:50 at a flow rate of 1.0 mL/min. Retention times of Salicylic acid and Ketoconazole were found to be 2.307 min, 3.342 min respectively. Method was found to be linear in the range of 5-30 μg/ml. Developed method was validated and stability studies were performed according to ICH guidelines and applied for the assay of the drugs in the shampoo formulation.
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