Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Spectroflourimetric determination of venlafaxine hydrochloride and odesmethylvenlafaxine in marketed formulations
Author(s): Ardeshna HH, Moradiya MR, Shah PA, Nakrani RS, Patel KG, Gandhi TRA simple, sensitive, precise and reproducible spectrofluorimetric method for the analysis of venlafaxine hydrochloride and O-desmethylvenlafaxine in pharmaceutical formulations has been developed. Venlafaxine hydrochloride and O-desmethylvenlafaxine are synthetic novel antidepressant drugs, and acts by inhibiting the reuptake of serotonin and noradrenaline. Venlafaxine hydrochloride exhibits maximum fluorescence intensity at excitation wavelength of 274 nm and emi s s i o n wa v e l e n g t h 610 nm, and similarly O-desmethylvenlafaxine at excitation wavelength 226 nm a n d emi s s i o n wa v e l en g t h 300 nm respectively. Beer’s law was obeyed for both Venlafaxine and O-desmethylvenlafaxine in the concentration range of 50-300 ng/ml and 10-600 ng/ml respectively. The limit of detection and limit of quantitation for venlafaxine and O-desmethylvenlafaxine were found to be 7.72 ng/ml, 23.40 ng/ml and 1.95 ng/ml, 5.91 ng/ml respectively. This simple, sensitive and precise method hence can be successfully employed for the routine determination of venlafaxine and O-desmethylvenlafaxine in various pharmaceutical preparations
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