Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Simultaneous estimation of cefuroxime axetil and potassium clavulanateanalytical method development and validation
Author(s): Pramod L. Ingale, Sampada D. Dalvi, Deepali D. Jadav, Sachin V. Gudi,Laxmileena D. Patil and Yogita A. KadamA simple, rapid and sensitive spectrophotometric method has been developed for simultaneous estimation of cefuroxime axetil and potassium clavulanate in combined dosage form. Maximum absorbance of cefuroxime axetil and potassium clavulanate was measured in methanol at 284 nm and 271nm. The calibration curve of both the drug obey’s the Beer’s Law in the concentration range 5-50μg/ml for cefuroxime axetil and 1-30μg/ml for potassium clavulanate with correlation coefficient value 0.999 and 0.998 at 284nm and 271nm respectively. The present method was validated as per ICH guidelines. The result obtained of this method were in good agreement recommended for routine analysis where time, cost effectiveness and high specificity of analytical techniques are of great importance.
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Citations : 15261
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