Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Regioselective synthesis of sugar fused dispiropyrrolizidines via intermolecular 1,3-dipolar cycloaddition reaction
Author(s): Sirisha Nallamala and Raghavachary RaghunathanAn expedient method for the synthesis of glyco dispiropyrrolizidines is reported through 1,3-dipolar cycloaddition reaction (1,3 DC reaction). The novel glycosyl dipolarophile derived from D-glucose underwent neat [3+2] cycloaddition reaction with the azomethine ylides generated from di/tri ketones and proline to give the corresponding glycosidic heterocycles in good yields.
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Citations : 15261
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