Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
QSAR Studies of Thiazolidinone Derivatives as Antimicrobial Agents
Author(s): Shyama Sharma, Sanjiv Kumar, Sumit Tahlan, Amita Suneja Dang and Balasubramanian NarasimhanQSAR (Quantitative Structure–Activity Relationship) relate biological activity data along with the physiochemical and structural properties of a group of compounds. In general, most of the medicinal compounds involve heterocyclic compounds containing nitrogen and sulphur especially thiazolidinones they possess a broad spectrum antimicrobial activity. In the present study, we have carried out the QSAR studies of antimicrobial thiazolidinones using Hansch analysis. The results of QSAR studies indicated that the antimicrobial activity of thiazolidinones are mainly governed by the topological parameters, kiers 3rd order alpha shape index (k a 3) and second order valence connectivity index (2χv) along with the lipophilic parameter, log of octanol water partition coefficient (log P).
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