Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Q-Absorbance and Multicomponent UV Spectrophotometric Methods for Simultaneous Estimation of Propranolol Hydrochloride and Flunarizine Dihydrochloride in Capsules
Author(s): Amod S. Patil, Atul A. Shirkhedkar*, Sanjay J. Surana, Prajakta S. NawaleTwo simple UV-Spectrophotometric methods have been developed for simultaneous determination of Propranolol hydrochloride(PRH) and Flunarizine dihydrochloride(FNZ) in capsule dosage form. Methanol was used as solvent. In Method-I (Q-absorbance absorbance ratio) involves formation of Q-absorbance equation at two wavelengths i.e. 272.8 nm (isoabsorptive point) and 253 nm (λ max of FNZ). While, in Method-II (Multicomponent Mode of Analysis) involves the measurement of absorbance at two wavelengths i.e. 289 nm, λ max of PRH and 253 nm, λ max of FNZ. In both these methods PRH and FNZ followed linearity in the concentration range of 08 - 48 μg/ml for PRH and 03 – 18 μg/mL for FNZ at their respective λ max. Both these methods were found to be accurate, precise and rugged as indicated by low values of % RSD. Both these methods were also found to be rapid and economical can successfully be applied for the routine analysis of PRH and FNZ in bulk and combined capsule dosage form.
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