Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Proficient One-pot, Multi-component Synthesis of Pyrano[2,3-c]pyrazole Derivatives Using C8[DABCO]Br as Catalyst in Aqueous Medium
Author(s): Imen Boualia, Sabrina Benelhadj, Abdelmadjid Debache, Raouf BoulcinaC8[DABCO]Br, an ionic liquid, was demonstrated to be a highly efficient catalyst for the synthesis of a series of pyranopyrazole derivatives via a one-pot, multi-component reaction of aldehydes, hydrazine hydrate, malononitrile, and β-ketoester in water. The catalyst was found to work extremely to give the corresponding dihydropyrano[2,3-c]pyrazoles in high yields. The salient features of this new methodology are broad substrate scope conditions, short reaction times, high yields, easy work-up process, and the absence of hazardous organic solvents.
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Citations : 15261
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