Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Potential Protective effect of Vitamin C on Cerebral Ischaemia Reperfusion Injury in Rats
Author(s): Bassant M.M. Ibrahim, Sahar E.S. Harraz and Ahlam H.MahmoudCerebral Ischaemia/reperfusion injury(I/RI)is a common cause of brain damage. The use of antioxidants has beneficial effects in I/RI, as they protect against brain damage by inhibiting reperfusion injury. The present study was conducted to investigate the role of vitamin C in the protection against cerebral I/RI, induced in rats and its effect on biomarkers of oxidative and nitrosative stress, and on markers of inflammation. Male rats were divided into six groups: The first was sham operated group, the second group was I/RI and the last four received intravenous (IV) vitamin C in doses 50 and 100mg/kg before and after I/RI. Reduced glutathione, malondialdehyde, nitric oxide, tumour necrosis factor alpha and interleukin one beta were measured in brain homogenates. Results showed that both doses of vitamin C given before and after I/RI induction had protective effect on brain tissue against I/RI
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
