Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Phenethylamide derivatives: Synthesis and evaluation of antimicrobial and antioxidant activity
Author(s): Chandrashekar Aswathanarayanappa*, Eswarappa Bheemappa, Yadav D Bodke, Raghu Ningegowda, Peethambar S KPhenethylamidediesters (2-6) were synthesized by reacting [3-ethoxy-4- (ethoxycarbonyl)phenyl]acetic acid with a series of C-protected aminoacids viz., Alanine, Proline, Phenylalanine, Tyrosine and 2-amino-5-(benzyloxy)-5-oxopentanoic aciddiesters and these compounds were hydrolyzed using sodium hydroxide to their respective diacids (7-11). The newly synthesized compounds were tested for antimicrobial activity against Escherichia coli, Staphylococcus Aureus, Pseudomonas Aeruginos,Aspergillus Flavus, ChrysosporiumKeratinophilum, Candida Albicansand antioxidant activity by DPPH method. Compounds 6, 7, 8, and 11 were most active as antimicrobials and 6, 10 and 11have shown promising antioxidant activity.
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Citations : 15261
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