Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Pharmacological Study of Some Newly Synthesized Furan Derivatives
Author(s): Sandip Sen, Biplab De, Lipika Panday, Trichy Siva Easwari, A.S.NagarajanFuran ring systems are abundantly available in secondary plant metabolites. Due to their remarkable properties, many synthetic furans are utilized as pharmaceuticals. Hence a series of N-(furan-2-ylmethylene) benz- imines derivatives has been synthesized by reaction between furan-2--carboxaldehyde and various aromatic anilines to yield the schiff,s bases. The newly synthesized compounds showed potent CNS depressant and analgesic activities. Prior to determination of the Pharmacological activity LD50 was determined. The pharmacological data obtained were tested for statistical significance.
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