Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Oxovanadium(V) complexes with hydrazone ligands: Synthesis, characterization and biological activity
Author(s): Jai Devi and Nisha Batra[VOSO4].5H20 with Pyrazine-2-carboxylic acid(phenyl-thiophene-2-yl-methylene)- hydrazide (HL1) and Pyrazine- 2-carboxylicacid (phenyl-pyridin-2-yl-methylene)-hydrazide (HL2), respectively, in methanol affords oxovanadium(V) complexes, [VO(SO4)L1] (I) and[VO(SO4)L2] (II). Both complexes have been characterized by elemental analysis and spectroscopic techniques (I.R, U.V, mass). The mononegative hydrazone ligands coordinate to the metal atoms through azomethine nitrogen, carbonyl oxygen and sulphur of thiophene ring (HL1)/ nitrogen of pyridine ring(HL2) and found to have square pyramidal geometry around each vanadium ion. Ligands and complexes were screened for in vitro antibacterial activity and antifungal activity at different concentrations against bacteria viz. Gram positive Bacillus subtilis, Micrococcus Luteus and Gram negative Pseudomonas aeruginosa, Pseudomonas mendocina and fungi Verticillum, Cladosporium, Tinospora. A distinct enrichment in biocidal activity of the ligands under similar experimental conditions was observed as a consequence of coordination with vanadium atom.
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