Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Optimized UV-Vis spectrophotometric method for estimation of anastrozole in pharmaceutical solid dosage form
Author(s): Mrityunjay Banerjee, Tejaswini Kumari Dash, Ankita Kumari, Swapneswar KhatuaA simple and valuable UV Spectrophotometric method was developed for anastrozole in bulk and in its pharmaceutical formulation using different solvent. The maximum absorbance (λmax) was found to be 263nm for acetate buffer (PH2.8). The calibration curve was in concentration range 10-50μg/ml. due its simplicity, rapidness, high precision and accuracy this method may be applied successfully for determining anastrozole in bulk and on tablet dosage formulation. The repeatability study was done for the precision of proposed method. All the results of analysis were validated according to the International Conference on Harmonization (ICH) guideline. This method has been successfully used to determine Anastrozole content in tablets of different origin and bulk mixtures.
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Citations : 15261
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