Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Novel pyrimidinone derivative as potential promising antimicrobial agent
Author(s): Vikas Kumar, Pratibha SinghSome new derivatives of 4-phenyl-5-[5'-(3''-chloro-2''-oxo-4''-substitutedaryl-1''-azetidinyl)- 1',3',4'-oxadiazol-2'-yl]-6-methyl-3,4-dihydropyrimidine-2-one and 4-phenyl-5-[5'-(2''- substitutedaryl- 4' '-oxo -1'',3''- thiazolidin -3''-yl) -1',3',4 '-oxadiazol-2'-yl]- 6- methyl-3,4- dihydro pyrimidin -2-one have been synthesized by reacting different substituted Schiff bases with chloroacetyl chloride and thioglycolic acid, respectively. The structures of synthesized compounds were confirmed by IR and 1H-NMR data. Antimicrobial activities of compounds were investigated using the standard method against different bacterial and fungal strains in comparison with standard drugs. Microbiological results indicated that the synthesized compounds possess a board spectrum of activity.
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