Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Novel fused thienopyridne and pyrazolopyridine derivatives: Synthesis, characterization and cytotoxicity
Author(s): Mohamed A. A. Elneairy, Sanaa M. Eldine and Ahmed S. I. MohamedSeveral new of fused thienopyridine and pyrazolopyridine derivatives were synthesized via the reactions of both compounds 2- Carbohydrazide 2 and 3-aminopyrazolopyridine 14 with a variety of active reagents and chemicals. Structures were established based on elemental and spectral data studies. Some of the synthesized compounds exploited potent antitumor activity, especially the pyridopyrazolotriazine 20c which displayed the highest activity among the tested compounds with the IC50 equal to 3.8μg/ml.
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Citations : 15261
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