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N-Acylation in non-aqueous and aqueous medium- method of amide synthesis in non-peptide compounds | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

N-Acylation in non-aqueous and aqueous medium- method of amide synthesis in non-peptide compounds

Author(s): Ambersing P. Rajput1 and Rambhau P. Gore*2

N-acylation in non-aqueous and aqueous medium i.e. Schotten-Baumann method of amide synthesis with carboxylic acid activating reagent such as thionyl chloride and Phosphinehalogen reagents have been discussed. Limitations, alternatives and applications of these reagents are illustrated.


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