Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Molecular Docking Studies of Cu(II) Complex: A Novel Therapeutic Alternative in Treating Staphylococcus aureus< and Related Complications
Author(s): Naveen Kumar RM, Govindaraju Shruthi, Shiva Prasad Kollur, Chandan Shivamallu, Mekhala N Chitagudigi, Prasad NCopper is one of the essential metal ions required by Staphylococcus aureus (S. aureus) as a cofactor for synthesis and activity of various enzymes which includes superoxide dismutase. Present work describes the computational studies, particularly, molecular docking investigations of Cu(II) complex in the inhibition of Superoxide Dismutase (SOD) produced in the pathogen S. aureus. The results from this study revealed that the Cu(II) complex will be readily taken up by the organism thereby facilitating easy inhibition or inactivation of SOD. This is due to high affinity of SOD towards copper core of the complex.
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