Abstract

Mini-review and Comparative Study: Preparation and Evaluation of Nicotine-loaded Buccal Mucoadhesive Tablets/films designed for Smoking Cessation

Author(s): Mona G. Arafaa, Bassam M. Ayoubc

Smoking is a major cause of cardiovascular diseases, respiratory diseases and cancer. Despite the high prevalence
of smokers worldwide, smokers are often neglected and not offered effective assistance with quitting their habits. In
order to overcome this public health burden, effective treatment is needed to help smokers stop smoking. Nicotine
replacement therapy is a way of getting nicotine into bloodstream without smoking. A number of smoking cessation
dosage forms have led to increases in quitting and thus to significant benefits to public health. Nicotine buccal
mucoadhesive dosage forms designed for smoking cessation have the advantage of not requiring chewing
accompanied with high bioavailability. This review covered all the previous pharmaceutical preparation and
evaluation of nicotine-loaded buccal mucoadhesive tablets/films since 2002 to 2016. The present concise review can
be used as a guide for those who are interested in design and evaluation of a new buccal mucoadhesive nicotine
formulation

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