Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Mild and efficient method for oxidation of alcohol to carboxylic acid followed by synthesis of amide analogues of Corey�¢����s lactone
Author(s): K. Venkata Rambabu, G. Mahesh Reddy, K. MukkantiA mild, safe and efficient method for the oxidation of Corey’s lactone to carboxylic acid under modified Anelli’s oxidation condition has been developed. The oxidation reaction proceeded at room temperature under biphasic reaction in DCM/water with high yield. Further, treatment of carboxylic acid with various amines was studied for the first time, resulting in the formation of amides in good to excellent yields.
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Citations : 15261
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