Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Microwave-Assisted One-Pot Synthesis of Novel Polyarylpyrrole Derivatives of Expected Anticancer Activity
Author(s): Ahmed Younis*, Ali M Hassan, Mohamed F Mady, El-Haddad AF, YassinFA and Mahmoud FayadAn efficient synthesis of Novel pyrrolederivatives was achieved via solventless reaction of chalcones 1(a-e) with different aldehydes 2(a-e) and ammonium acetate in the presence of sodium cyanide in one-pot under microwave irradiation. The notable features are short reaction time, high yield and purification of product by non-chromatographic methods, i.e., by simple recrystalization compared to the classical condition. Some of the synthesized compounds were evaluated against HepG-2, and showed significant antitumor activities.
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Citations : 15261
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