Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Microwave assisted synthesis of N-substituted Pyrimidines Using AlCl3 as catalyst and their antimicrobial Activities
Author(s): Mukesh M. Chavda, Manish J. Solanki, Jasmin J.Solnki Chetna M. Rajyguru, Jatin M. UpadhyayThe three component condensation of an aldehyde, Substituted urea and 3-oxobutanamide in presence of catalytic amount of AlCl3 is disclosed for the synthesis of pyrimidine under solvent free microwave irradiation conditions. High yields are achieved even 1 g scale, while reaction times are considerably shortened compare to conventional method The antimicrobial activities of the pyrimidines (1a-t) are compared with those of known chosen standard drugs, viz. ampicillin, chloramphenicol, ciprofloxacin, norfloxacin and griseofulvin.
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