Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Microwave assisted synthesis, antifungal evaluation and moleculer docking of benzimidazole derivatives
Author(s): Rani S. Kankate, Parag S. Gide and Deepak P. BelsareA novel series of biphenyl carbonyl piperazine moiety carrying benzimidazole derivatives, based on an initial design by molecular docking study of this scaffold at the active site of the fungal enzyme of cytochrome P450 family, lanosterol 14 α -demethylase (CYP51) was synthesized by microwave irradiation. The synthesized compounds were characterized by elemental and spectral analysis (IR, 1H NMR and mass spectrometry).The screening of the synthesized compounds for invitro antifungal activity against Candida albicans revealed activity in many of the compounds as comparable to that of ketoconazole.
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Citations : 15261
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