Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Microsponge: An Innovative and Novel Strategy for Drug Delivery System
Author(s): Shweta Saboo* and Yogesh BhiseThe microsponge approach has become a highly competitive and rapidly evolving technology. They are porous, highly cross-linked, polymeric microspheres that can be efficiently incorporated into topical drug delivery systems for the purpose of release and retention of dosage form on the skin over a long period of time. Furthermore, they may modify drug release, enhance stability, improve patient compliance and reduce side effects. microsponge systems are non-toxic, non-irritating, non-mutagenic and non-allergenic. In general, there are multiple methods used to manufacture microsponges, such as the quasi-emulsion solvent diffusion method and liquid-liquid suspension polymerization. The present review focuses on the microsponge preparation methods along with its principle and characterization such as Particle size and distribution, porosity, density and surface morphology and release mechanis and drugs incorporated in the Microsponges Drug Delivery System (MDS).
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Citations : 15261
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