Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Metallic and non metallic nanoparticles incorporated meropenem and ceftazidime synthesis for the improved antibacterial activity against human pathogenic bacteria
Author(s): S. Karthick Raja Namasivayam, Varinder Singh and S. SamyduraiIn the present study improved antibacterial activity of meropenem and ceftazidime incorporated with free and chitosan coated egg albumin nanoparticles, silver nanoparticles against Escherichia coli and Salmonella paratyphi has been carried out. Egg albumin nanoparticles incorporated drugs were synthesized by coacervation method and chitosan coated nnao drug conjugate by ionic gelation method. Synthesized nano drug conjugates were characterized by scanning electron microscopy (SEM),energy dispersive x ray spectroscopy (EDX) and Fourier Transform Infrared spectroscopy (FTIR).All the nanoformulations showed distinct antibacterial activity against both the tested bacteria and further studies will be helpful to formulate in bulk volume and commercialization possible through proper clinical trials
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Citations : 15261
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