Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Isolation and Cytotoxic Activity Test Methyl Gallate Compounds from Shorea Singkawang Bark in P388 Murine Leukemia Cell
Author(s): Yusnelti, Yunazar Manjang, Abdi Dharma and Djaswir DarwisIn this research we has isolated and tested the activity of phenolic compounds methyl gallate group of ethyl acetate fraction from the bark of Shorea singkawang. Cytotoxic test was conducted using Brimp Shrimp Lethality Test (BSLT). Analysis and structure determination by spectroscopic methods UV, IR, GC-MS and NMR (1H-NMR, and 13CNMR). From the test results showed cytotoxic ethyl acetate extract is toxic with LC50 = 2.05 μm/mL and bioactivity in P388 murine leukemia cell, IC50 value of 1.66 μm/mL. Meanwhile, test cyto-toxicity using fry shrimp Artemia salina Leach using Brine Shrimp Lethality Bioassay methyl gallate showed LC50 = 1.81 μm / mL is a compound that is toxic and can inhibit P388 murine leukemia cell with IC50 values below the compound its standard 4 μm/mL.
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