Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Ionotropic Glutamate Receptor Subtype 6: Docking and Site Moiety Map Analysis Study
Author(s): Ashwani Kumar, Anupama, Sandeep JainIn an attempt to discover more potent ligands, we present here a docking study for ionotropic glutamate receptor subtype 6 which is important in many neurodegenerative diseases. Total 97 compounds including a small series of commercially available compounds are characterized in iGluR6 binding. Z-scores were employed to recognize hits for this receptor. Twenty eight compounds were shown to have excellent binding affinity on this target. A detailed in silico study showed the strong interactions of compound no. 2h and 13515655 with iGluR6. Total four anchors were found. They involve three hydrogen bonding interactions and one vander waal interaction.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
