Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Ionic liquid mediated safer synthetic routes for schiff bases and 1,3,4-oxadiazoles
Author(s): Vasant B. Jagrut, Wamanrao N. Jadhavb,Dinesh L. Lingampallec and Ramrao A. ManedAn efficient and greener synthetic protocol for the synthesis of 1,3,4-oxadiazoles, N-{4-[4-acetyl-5-(4-substitutedphenyl)- 4,5-dihydro-[1,3,4]oxadiazol-2-yl]-phenyl}-4-methyl-benzenesulfonamide (6a-g) has been developed using 4-amino benzoic acid (1) as starting material. Attempts were made to synthesize required precursors by employing green tools. The route is found to be rapid, eco-friendly, easier to work and gives better yields of the intermediates and titled products.
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Citations : 15261
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