Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Ionic liquid is an efficient catalyst for Knoevenagel condensation under grinding method
Author(s): Kiran F. Shelkea and Ravi E. KhadseA simple, green and environmentally benign route has been developed for the Knoevenagel condensation of 4-oxo- (4H)-1-benzopyran-3-carbaldehydes and 2-chloroquinoline-3-carbaldehyde with various active methylene compounds viz. malononitrile, ethylcyanoacetate, cyanoacetic acid, cyanoacetamide and Meldrum’s acid were carried out in the presence of catalytic amount of basic ionic liquid 1-benzyl-3-methylimidazolium hydroxide ([bnmim]OH) by grinding method. The remarkable advantages of the present method are mild reaction conditions, short reaction time, excellent yields and green aspects by avoiding toxic catalyst and hazardous solvent. Additionally, the ionic liquid was successfully reused for four cycles without significant loss of activity.
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Citations : 15261
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