Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
In-Vitro Alpha-Amylase Inhibitor Activity and Antioxidant Activity of Actinobacteria Isolated from Marine Sediment Samples
Author(s): Elizabeth Mathew, Haimanti Mondal, Priyanka Kharat, Purbasha Saha and KV Bhaskara Rao*Marine environment is a diverse and untapped source of a wide variety of biologically active compounds. Among several organisms, marine actinomycete has been known to be a potential source for novel enzymes. Diabetes mellitus is a long term metabolic disorder characterized by hyperglycaemia. In the present study, marine actinobacteria isolated from the marine sediments of the coastal areas of Kothapattanam, Ongole, Andhra Pradesh, were used to screen for alpha-amylase inhibitor and antioxidant compounds, which are known to manage type 2 diabetes. A total of 20 actinobacteria were isolated from the marine sediments. Among the 20 isolates, an actinobacterial isolate designated VITMA1 showed 58.16% inhibition against alpha amylase enzyme. Further, VITMA1 also exhibited antioxidant activity. It showed 61.82% of DPPH radical scavenging activity, reducing power at 1.933 and a metal chelating activity of 20.33% respectively. The combined effect of antioxidant activity and alpha-amylase enzyme inhibition makes the secondary metabolite obtained from marine actinobacterial isolate, a potent anti-diabetic drug. Based on phenotypic characteristics, VITMA1 was identified upto the genus level as Streptomyces sp.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
